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W36 小野光弘研究報告

2012年5月21日

工業会会員の皆様へ
            W36小野光弘 (現在、小野研究室(自営)代表)

 私は1961年3月に山大工学部電気工学科2コースを卒業し、その1年後から母校に奉職、42年間、研究と教育にたずさわりました。在職中、皆様方から頂いた多大のご指導とご支援に厚くお礼申し上げます。この度、工業会のご好意により、その間発表させて頂いた研究論文等のリストをこの場に掲載して頂けることになりました。併せてお礼申し上げます。

以下の論文等は、著者の一人小野が母校を定年退職するのを機会に、1984年から2004年までの20年間、ならびにその後の客員教授としての数年間に、小野研究室ならびに関連の研究室において行われたインビボ(in vivo、生きたままでの)電子常磁性共鳴(EPR)(又は電子スピン共鳴(ESR))に関する研究の成果をまとめたものです。

 暗中模索で始めた研究でありましたが、開始後間もなく電気シールド付ループ・ギャップ共振器の着想を得て、1mM TEMPOL 水溶液からのEPR信号取得に成功しました。その結果を1985年開催のESR討論会にて発表したところ一大センセーションが巻き起こりました。当時を思い出すよすがとして、論文リストの始めに1985年開催のESR討論会予稿および1986年電子情報通信学会マイクロ波研究会予稿のタイトルを記します。その後、生きたセロリ及びマウスからのEPRイメージング信号の取得に成功し、間もなく日本電子(株)から電気シールド付ループ・ギャップ共振器を用いたLバンドESRアタッチメントが実用化されました。その装置は、現在、国内外の30を超える研究機関で使われています。

当初の研究者は、学内では小野、謝(敬称略、以下同じ)、鈴木、尾形等、学外では福島県立医科大学土橋、石田等でありましたが、小野はその後、研究室を平田と構成し、共振器、電子回路、EPR法の研究に取り組んで今日に至っています。2003年には、以上の研究の締めくくりとしてInternational Symposium on the Instrumentation of EPR Spectroscopy を米沢にて開催し、若手研究者が気鋭の研究者と親しく討論する場を設けました。
 これらの研究論文等が今後のin vivo EPR 研究に少しでもお役に立てればと願っています。

CONTENTS

Part One: Brief Prints

Introduction

(1) L-band ESR with a loop-gap resonator, M. Ono, K. C .Hsieh, M. Suzuki, T. Ogata, E. Yoshida and H. Kamada, 24th ESR Symposium, pp. 63-65 (1985) (in Japanese).

(2) On a loop-gap resonator with an electric shield, M. Ono, K. C. Hsieh, M. Suzuki, M. Akashi, T. Ogata, H. Susaki, E. Yoshida and H. Kamada, IEICE Technical Report on Microwaves, vol. MW86-90, pp. 63-70 (1986) (in Japanese).

Part Two: Original Papers

Loop-Gap Resonator

(3) L-band ESR spectrometer using a loop-gap resonator for in vivo analysis, M. Ono, T. Ogata. K. C. Hsieh, M. Suzuki, E. Yoshida, and H. Kamada, Chemistry Letters, pp. 491-494 (1986).

(4) Visualization of eddy-current losses in L-band ESR imaging, T. Ogata, Y. Ishikawa, M. Ono, L. J. Berliner, Journal of Magnetic Resonance, Vol. 97, pp. 616-622 (1992).

(5) Design of a multi-coupled loop-gap resonator used for pulsed electron paramagnetic resonance measurements, Y. Sakamoto, H. Hirata and M. Ono, IEEE Transactions on Microwave Theory and Techniques, Vol. 43, No. 8, pp. 1840-1847 (1995).

(6) Resonance frequency estimation of a bridged loop-gap resonator used for magnetic resonance measurements, H. Hirata, M. Ono, Review of Scientific Instruments, Vol. 67, No. 1, pp. 73-78 (1996).

(7) Experimental investigation of RF magnetic field homogeneity in a bridged loop-gap resonator, M. Ono, A. Suenaga, and H. Hirata, Magnetic Resonance in Medicine, Vol. 47, No. 2, pp. 415-419 (2002).

Surface- Coil Resonator and Impedance-Matching System

(8) A surface-coil-type resonator for in vivo ESR measurements, M. Ono, K. Ito, N. Kawamura, K. C. Hsieh, H. Hirata, N. Tsuchihashi, and H. Kamada, Journal of Magnetic Resonance, Series B, Vol. 104, pp. 180-182 (1994).

(9) Analysis of a flexible surface-type resonator for magnetic resonance measurements, H. Hirata, H. Iwai, and M. Ono, Review of Scientific Instruments, Vol. 66, No. 9, pp. 4529-4534 (1995)

(10) An improved inductive coupler for suppressing a shift in the resonance frequency of electron paramagnetic resonance resonators, H. Hirata, T Walczak, and H. M. Swartz, Review of Scientific Instruments, Vol. 68. 8. Pp. 3187-3191 (1997).

(11) Impedance-matching system for a flexible surface-coil-type resonator, H. Hirata and M. Ono, Review of Scientific Instruments, Vol.68, No. 9, pp. 3528-3532 (1997).

(12) A flexible surface-coil-type resonator using triaxial cable, H. Hirata and M. Ono, Review of Scientific Instruments, Vol. 68, No. 9, pp. 3595-3596 (1997).

(13) Electronically tunable surface-coil-type resonator for L-band EPR spectroscopy, H. Hirata, T. Walczak, and H. M. Swartz, Journal of Magnetic Resonance, Vol. 142, No. 1, pp. 159-167 (2000).

(14) Characteristics of an electronically tunable surface-coil-type resonator for L-band electron paramagnetic resonance spectroscopy, H. Hirata, T. Walczak, and H. M. Swartz, Review of Scientific Instruments, Vol. 72, No. 6, pp. 2839-2841 (2001).

(15) Mapping of the B1 field distribution of a surface coil resonator using EPR imaging, G. He, S. P. Evaleppan, H. Hirata, Y. Deng, S. Petryakov, P. Kuppusamy, and J. L. Zweiwer, Magnetic Resonance in Medicine, Vol. 48, No. 6, pp. 1057-1062 (2002).

(16) An improved external loop resonator for in vivo L-band EPR spectroscopy, I. Salikhov, H. Hirata, T. Walczak, and H. M. Swartz, Journal of Magnetic Resonance, Vol. 164, No.1, pp. 54-59 (2003).

A Composite Resonator Assembly

(17) A composite resonator assembly suitable for EPR/NMR coregistration imaging, Shingo Matsumoto, Miki Nagai, Kenichi Yamada, Fuminori Hyodo, Keiji Yasukawa, Masahiro Muraoka, Hiroshi Hirata, Mitsuhiro Ono, Hideo Utsumi, Concepts in Magnetic Resonance Part B: Maganetic Resonance Engineering, Vol. 25B, Issue 1, pp. 1-11 (2005).

AFC and AMC

(18) Stability analysis and design of automatic frequency control system for in vivo EPR spectroscopy, H. Hirata and Z.-W. Luo, Magnetic Resonance in Medicine, Vol. 46, No. 6, pp. 1209-1215 (2001); Erratum Vol. 49, No. 5, p.977 (2003).

(19) Control characteristics of an automatic matching control system for in vivo EPR spectroscopy, H. Hirata, Y. Yamaguchi, T. Takahashi, and Z.-W.-Luo, Magnetic Resonance in Medicine, Vol. 50, No.1, pp. 223-227 (2003).

FM-EPR

(20) 1.1-GHz continuous-wave EPR spectroscopy with a frequency modulation method, H. Hirata, M. Ueda, M. Ono, and Y. Shimoyama, Journal of Magnetic Resonance, Vol. 155, No.1, pp. 140-144 (2002).

(21) Detection of electron paramagnetic resonance absorption using frequency modulation, H. Hirata, T. Kuyama, M. Ono, and Y. Shimoyama, Journal of Magnetic Resonance, Vol. 164, No.2, pp. 233-241 (2003).

(22) A frequency modulation detection scheme of electron paramagnetic resonance spectroscopy, M. Ono, Y. Asahi, Y. Shimoyama, Bull. Yamagata Univ. (Eng), vol.28, No. 1 (2004).

(23) Nonequivalent spectra of unpaired electrons in field and frequnecy modulation, Hiroshi Hirata, Toshifumi Kuyama, Mitsuhiro Ono, Yuhei Shimoyama, Journal of Magnetic Resonance, Vol. 168, Issue 2, pp. 252-258. (2004).

in vivo EPR Spectroscopy

(24) An example of in vivo analysis by L-band ESR technique using a loop-gap resonator, T. Ogata, M. Ono, T. Fujisawa, E. Yoshida, H. Kamada, Chemistry Letters, pp. 1681-1684 (1986). P.125

(25) In vivo analysis of nitroxide radius injected into small animals by L-band ESR technique, S. Ishida, H. Kumashiro, N. Tsuchihashi, T. Ogata, M. Ono, H. Kamada, E. Yoshida, Phys. Med. Biol., 1989, Vol. 34, No. 9, 1317-1323.

(26) Electron spin resonance imaging of the distribution of the nitroxide radical administered into mouse legs, S. Ishida, S. Matsumoto, H. Yokoyama, N. Mori, H. Kumashiro, N. Tsuchihashi, T. Ogata, M. Ono, H. Kamada, E. Yoshida, Journal of Magnetic Resonance, Vol. 10, No. 1 (1990).

(27) An ESR-CT imaging of the head of a living rat receiving an administration of a nitroxide radical, S. Ishida, S. Matsumoto, H. Yokoyama, N. Mori, H. Kumashiro, N. Tsuchihashi, T. Ogata, Y. Yamada, M. Ono, T. Kitajima, H. Kamada and E. Yoshida, Magnetic Resonance Imaging, Vol. 10, No. 1 (1992).

(28) In vivo ESR measurement of radical reaction in skin of porphyria model mouse under light irradiation, T. Takajyo, K. Takeshita, H. Hirata, M. Ono, and H. Utsumi, Magnetic Resonance In Medicine, vol. 10 (1999).

(29) Application of in vivo ESR spectroscopy to in vivo detection of radicals produced in skin during irradiation of ultraviolet light, K. Takeshita, C. Chi, H. Hirata, M. Ono, H. Susaki, T. Ozawa, Magnetic Resonance In Medicine, Vol. 12 (2001).

(30) In Vivo Oxygen Radical Generation in the Skin of the Protporphyria Model Mouse with Visible Light Exposure: An L-Band ESR Study, Keizo Takeshita, Tokuko Takajo, Hiroshi Hirata, Mitsuhiro Ono and Hideo Utsumi, Journal of Investigative Dermatology, Vol 122, pp. 1463-1470, (2004).

(31) In vivo generation of free radicals in the skin of live mice under ultraviol light, measured by L-band EPR spectroscopy, Keizo Takeshita, Cuiping Chi, Hiroshi Hirata, Mitsuhiro Ono, Toshihiko Ozawa, Free Radical Biology and Medicine, Vol. 40, Issue 5, pp. 876-885, (2006).

(32) Heterogeneity of Regional Redox Status and Relation of the Redox Status to Oxygenation in a Tumor Model, Evaluated Using Electron Paramagnetic Resonance Imaging, Keizo Takeshita, Kumiko Kawaguchi, Kaori Fujii-Aikawa, Megumi Ueno, Shoko Okazaki, Mitsuhiro Ono, Murali C. Krishna, Periannan Kuppusamy, Toshihiko Ozawa, and Nobuo Ikota, Cancer Research, Vol. 70, (2010).

Part Three: Proceedings

(33) Development of pulsed L-band ESR spectrometer, M. Ono, K. Ito, E. Yoshida, S. Sekimukai, and H. Kamada, IMTC ’94, held in Hamamatsu, Japan (1994).

(34) International symposium on the Instrumentation of EPR Spectroscopy –in commemoration of Professor Ono for his contributions to EPR and Microwave Engineering-, held in Yonezawa, Japan (2003).

Part Four: Reviews

(35) Quantum computing based upon EPR spectroscopy, A. Suenaga, M. Ono and Y. Shimoyama, Applied Physics Education, Vol. 24, No.2, (2000) (in Japanese).

(36) Low frequency ESR instrumentation, H. Hirata and M. Ono, Electron Spin Science, vol. 1, SEST (2003) (electronic publication in Japanese).